Modulation of macrophage proliferation by hyperglycemia

Mol Cell Endocrinol. 1995 Oct 30;114(1-2):187-92. doi: 10.1016/0303-7207(95)96799-n.


Macrophages have been show to be of importance in three areas of pathology in the diabetic state: (a) in the destruction of the beta cells of the pancreas; (b) in the pathogenesis of the microvascular lesions; and (c) in the atherosclerotic lesion which is a common complication of diabetes. However, there is only scanty information on the behavior of the macrophage in the hyperglycemic environment. The present study investigates the growth of WEHI-3 monocytes/macrophages and the proliferative response of splenic macrophages to colony stimulating factor-1 when cultured in media containing high glucose concentrations. The results of the study show that hyperglycemia increases the proliferation of these macrophages; this effect is not mediated by the effect of osmolality since mannitol and L-glucose failed to produce a similar result. These findings suggest that alterations of macrophage physiology may be an important component of the diabetic state; such alterations may have a role in the production of some of the lesions found in diabetes mellitus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Division / drug effects
  • Cell Line
  • Culture Media
  • Diabetes Mellitus / etiology
  • Glucose / pharmacology
  • Humans
  • Hyperglycemia / metabolism
  • Hyperglycemia / pathology*
  • Macrophage Colony-Stimulating Factor / pharmacology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Macrophages / pathology*
  • Mice
  • Thymidine / metabolism


  • Culture Media
  • Macrophage Colony-Stimulating Factor
  • Glucose
  • Thymidine