Human skin contains luteinizing hormone/chorionic gonadotropin receptors

J Clin Endocrinol Metab. 1996 Jul;81(7):2738-41. doi: 10.1210/jcem.81.7.8675605.


Normal human skin contains a major 4.5 kb and several minor mRNA transcripts and a 66 kDa protein of luteinizing hormone (LH)/chorionic gonadotropin (hCG) receptors which are capable of binding exogenous 125I-hCG. The distribution of receptor transcripts and receptor protein are the highest in epidermis followed by hair follicles, sebaceous and sweat glands. LH/hCG receptors are co-localized with androgen receptors in all the skin appendages. These data are the first demonstration of skin containing LH/hCG receptors and would suggest that LH and hCG may regulate skin functions.

MeSH terms

  • Chorionic Gonadotropin / metabolism
  • Female
  • Humans
  • Immunoenzyme Techniques
  • In Situ Hybridization
  • Iodine Radioisotopes
  • RNA, Messenger / analysis
  • Receptors, Androgen / analysis
  • Receptors, LH / analysis*
  • Receptors, LH / genetics
  • Skin / chemistry*
  • Tissue Distribution


  • Chorionic Gonadotropin
  • Iodine Radioisotopes
  • RNA, Messenger
  • Receptors, Androgen
  • Receptors, LH