Progressive systemic sclerosis sine scleroderma which developed after exposure to epoxy resin polymerization

J Dermatol. 1996 May;23(5):344-6. doi: 10.1111/j.1346-8138.1996.tb04028.x.


Progressive systemic sclerosis (PSS) sine scleroderma is well known as a special form of scleroderma. Because of its rarity, its pathogenesis has not yet been elucidated. We experienced a 33-year-old man who developed PSS sine scleroderma while working with epoxy resin polymerization. He had short white frenulum linguae, diffuse hyperpigmentation and facial telangiectasia, positive antinuclear antibody, and pulmonary dysfunction, but not acrosclerosis or sclerodactylia. Modest dermal collagen proliferation in the forearm skin confirmed PSS sine scleroderma. Epoxy resin polymerizer appears to be a potent causative agent for PSS sine scleroderma as well as for generalized morphea-like PSS.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Epoxy Resins / adverse effects*
  • Humans
  • Male
  • Occupational Diseases / chemically induced*
  • Polymers
  • Scleroderma, Systemic / chemically induced*


  • Epoxy Resins
  • Polymers