Betulinic Acid and Dihydrobetulinic Acid Derivatives as Potent anti-HIV Agents

J Med Chem. 1996 Mar 1;39(5):1016-7. doi: 10.1021/jm950922q.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Giant Cells / drug effects
  • HIV Reverse Transcriptase
  • HIV-1 / drug effects*
  • HIV-1 / enzymology
  • HIV-1 / physiology
  • Humans
  • Molecular Structure
  • RNA-Directed DNA Polymerase / metabolism
  • Reverse Transcriptase Inhibitors / pharmacology
  • Structure-Activity Relationship
  • Triterpenes / chemistry
  • Triterpenes / pharmacology*
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Reverse Transcriptase Inhibitors
  • Triterpenes
  • dihydrobetulinic acid
  • betulinic acid
  • HIV Reverse Transcriptase
  • RNA-Directed DNA Polymerase