An African Swine Fever Virus Bc1-2 Homolog, 5-HL, Suppresses Apoptotic Cell Death

J Virol. 1996 Jul;70(7):4858-63.

Abstract

Here, we show that the African swine fever virus 5-HL gene is a highly conserved viral gene and contains all known protein domains associated with Bcl-2 activity, including those involved with dimerization, mediating cell death, and protein-binding functions, and that its protein product, p21, suppresses apoptotic cell death in the mammalian lymphoid cell line FL5.12. Thus, 5-HL is a true functional viral member of the Bcl-2 gene family.

MeSH terms

  • African Swine Fever Virus / genetics
  • African Swine Fever Virus / physiology*
  • Amino Acid Sequence
  • Animals
  • Apoptosis*
  • Base Sequence
  • Cell Line
  • Cell Line, Transformed
  • Humans
  • Interleukin-3 / metabolism
  • Mice
  • Molecular Sequence Data
  • Proto-Oncogene Proteins / chemistry*
  • Proto-Oncogene Proteins c-bcl-2
  • Sequence Homology, Amino Acid
  • Viral Proteins / chemistry
  • Viral Proteins / genetics
  • Viral Proteins / physiology*

Substances

  • 5-HL protein, African swine fever virus
  • Interleukin-3
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Viral Proteins

Associated data

  • GENBANK/L08246
  • GENBANK/L16462
  • GENBANK/L22473
  • GENBANK/L26545
  • GENBANK/Q07440
  • GENBANK/U16811
  • GENBANK/X59988
  • GENBANK/Z23116