Origin of blood-group antigens: a self-declaration mechanism in somatic cell society

Med Hypotheses. 1996 Mar;46(3):290-4. doi: 10.1016/s0306-9877(96)90258-3.


Blood-group antigens have been developed as a self-declaration mechanism in higher organisms, since blood cells carry different DNA from that of germ-line cells, and their selfishness must be strictly limited. If not, symbiosis between somatic DNA and germ-line DNA cannot be maintained since blood cells can express autonomy programmed within themselves. For the sake of maintenance of symbiosis, this self-declaration is not limited to blood cells and all somatic cells need a self-plural declaration mechanism such as blood-group antigens. Differentiation and development including induction and inhibition also depend on the self-declaration--recognition mechanism.

MeSH terms

  • Animals
  • Antibody Diversity
  • Blood Group Antigens / genetics*
  • Cell Communication
  • DNA / genetics
  • Gene Expression / physiology
  • Germ Cells / physiology
  • Hematopoietic Stem Cells / physiology*
  • Homeostasis / physiology
  • Humans
  • Isoantigens / genetics


  • Blood Group Antigens
  • Isoantigens
  • DNA