Is peritoneal permeability an adverse risk factor for malnutrition in CAPD patients?

Miner Electrolyte Metab. 1996;22(1-3):97-101.

Abstract

In light of the correlation between the dialysate to plasma ratio of creatinine (D/P Cr), peritoneal (PD) protein loss and hypoalbuminaemia, peritoneal permeability has been implicated as a risk factor for malnutrition in CAPD patients. However, serum albumin is also affected by hydration which is itself influenced by peritoneal permeability. In a cross-sectional study of 147 CAPD patients we investigated the relationship between peritoneal permeability, PD protein loss and nutritional state. Stepwise regression analysis revealed D/P Cr to be the only significant predictor of serum albumin independent of PD protein loss. No significant relationship was demonstrated between D/P Cr, body fat, lean muscle mass and dietary protein intake. Increased peritoneal permeability does not cause hypoalbuminaemia as a consequence of increased PD protein loss, and does not adversely affect somatic fat and protein status.

Publication types

  • Comparative Study

MeSH terms

  • Analysis of Variance
  • Anthropometry
  • Blood Proteins / metabolism
  • Body Composition
  • Creatinine / metabolism
  • Cross-Sectional Studies
  • Humans
  • Muscle, Skeletal / physiopathology
  • Nutrition Disorders / epidemiology*
  • Nutrition Disorders / etiology
  • Peritoneal Cavity
  • Peritoneal Dialysis, Continuous Ambulatory / adverse effects*
  • Permeability
  • Prealbumin / metabolism
  • Proteins / metabolism
  • Regression Analysis
  • Risk Factors
  • Serum Albumin / analysis
  • Serum Albumin / metabolism

Substances

  • Blood Proteins
  • Prealbumin
  • Proteins
  • Serum Albumin
  • Creatinine