Radioresistant DNA synthesis in fibroblast cell lines derived from LEC strain rats

Mutat Res. 1996 Jun 10;352(1-2):117-21. doi: 10.1016/0027-5107(96)00017-6.


Immortalized cell lines from LEC strain (LEC) rats by SV40 large T antigen were more sensitive to X-irradiation than the cell lines from WKAH strain (WKAH) rats. The dose-response curves for inhibition of DNA synthesis in WKAH-derived cells showed a steep decline at low doses and a shallow decline at high doses. On the contrary, the dose-response curves for LEC-derived cell lines showed no steep component; they were almost identical to the shallow component of the curves for WKAH-derived cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Polyomavirus Transforming
  • Cell Division
  • Cell Line, Transformed
  • Cell Survival
  • DNA Replication / radiation effects*
  • Dose-Response Relationship, Radiation
  • Fibroblasts / cytology
  • Fibroblasts / radiation effects*
  • Lung
  • Radiation Tolerance
  • Rats
  • Simian virus 40 / immunology


  • Antigens, Polyomavirus Transforming