High incidence of undetected neoplasia in maldescended testes

Lancet. 1979 May 12;1(8124):999-1000. doi: 10.1016/s0140-6736(79)92754-5.


Testicular biopsy specimens from 4 (8%) of 50 men previously treated for maldescended testes had a carcinoma-in-situ pattern. 2 of these men had adjacent invasive carcinoma (seminoma and embryonal carcinoma). The patient with embryonal carcinoma had an enlarged testis but the 3 other patients with neoplasia had no clinical signs or symptoms of malignancy. Routine follow-up including testicular biopsy in young men with maldescended testes is essential because of the increased risk of malignancy and may detect testicular neoplasia at a stage when orchidectomy alone is curative.

MeSH terms

  • Adolescent
  • Adult
  • Atrophy
  • Biopsy
  • Cryptorchidism / pathology*
  • Dysgerminoma / pathology
  • Humans
  • Male
  • Risk
  • Teratoma / pathology
  • Testicular Neoplasms / pathology*
  • Testis / pathology