Interleukin 8 and granulocyte elastase alpha 1 proteinase inhibitor complex in the tracheobronchial aspirate of infants with chronic lung disease following inter-uterine infection

Acta Paediatr Jpn. 1996 Apr;38(2):132-6. doi: 10.1111/j.1442-200x.1996.tb03455.x.


In order to elucidate the role of interleukin 8 (IL-8) in the development of chronic lung disease (CLD) of neonates with intra-uterine infection, serial and simultaneous measurements of the concentration of IL-8 and granulocyte elastase alpha 1 proteinase inhibitor complex (E-alpha 1 PI) in the tracheobronchial aspirate of low birth weight infants were conducted. Infants with a high serum IgM level at birth, and who subsequently developed CLD, showed significantly high concentrations of IL-8 and E-alpha 1 PI in the first 48 h. It seemed that IL-8 stimulated neutrophils to release neutrophil enzymes which, in turn, caused the lung tissue injury, resulting in the development of CLD following intra-uterine infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bronchi / metabolism*
  • Fetal Diseases*
  • Granulocytes / enzymology*
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Infections / complications*
  • Interleukin-8 / metabolism*
  • Leukocyte Elastase*
  • Lung Diseases, Obstructive / etiology
  • Lung Diseases, Obstructive / metabolism*
  • Pancreatic Elastase / metabolism*
  • Suction
  • Trachea / metabolism*
  • alpha 1-Antitrypsin / metabolism*


  • Interleukin-8
  • alpha 1-Antitrypsin
  • alpha 1-antitrypsin-leukocyte elastase complex
  • Pancreatic Elastase
  • Leukocyte Elastase