Metal ion induced autoimmunity

Curr Opin Immunol. 1995 Dec;7(6):831-8. doi: 10.1016/0952-7915(95)80056-5.

Abstract

Metal-induced autoimmunity is a well established but poorly understood phenomenon. Recent work has begun to elucidate the molecular interactions of metal ions with immune cells and self-proteins. Metal-induced presentation of cryptic self-peptides emerges as a possible mechanism for activation of 'metal-specific' T cells, challenging the hypothesis of a random polyclonal activation of T and B cells by metals. A preferential T-helper cell type 2 response is involved in metal ion induced systemic autoimmune disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoantigens / immunology
  • Autoimmune Diseases / chemically induced*
  • Autoimmunity*
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism
  • Cytokines / biosynthesis
  • Cytokines / immunology
  • Haptens / immunology
  • Humans
  • Lymphocyte Activation
  • Metals / immunology*
  • Mice
  • Models, Immunological
  • Rats
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism

Substances

  • Autoantigens
  • Cytokines
  • Haptens
  • Metals