Orthopedic aspects of myelodysplasia in children

Curr Opin Pediatr. 1996 Feb;8(1):65-7. doi: 10.1097/00008480-199602000-00014.


A review of new developments in spina bifida shows that many cases are preventable by administration of periconceptual folic acid, reducing the relative risk by up to 86%. Currently, however, 50% of women of reproductive age have no folic acid in their usual diet. The Centers for Disease Control as recommended folic acid at 0.4 mg/d for all women anticipating pregnancy. The long-term outcomes of sacral level patients show a surprising decline in adult ambulatory status. Adult ambulatory status in spina bifida is significantly predictive (89% accurate) by two variables: motor level and sitting balance. Studies regarding hip dislocation, foot deformities in thoracic level children, the prevalence of spondylolisthesis, and surgical treatment of kyphosis are also reviewed.

Publication types

  • Review

MeSH terms

  • Child
  • Folic Acid / therapeutic use
  • Hematinics / therapeutic use
  • Humans
  • Kyphosis / physiopathology
  • Kyphosis / prevention & control
  • Meningomyelocele / physiopathology
  • Meningomyelocele / prevention & control
  • Neural Tube Defects* / physiopathology
  • Neural Tube Defects* / prevention & control
  • Neural Tube Defects* / therapy
  • Prognosis
  • Spinal Dysraphism / physiopathology
  • Spinal Dysraphism / prevention & control


  • Hematinics
  • Folic Acid