Bacteria closely resembling Helicobacter pylori detected immunohistologically and genetically in resected gallbladder mucosa

J Gastroenterol. 1996 Apr;31(2):294-8. doi: 10.1007/BF02389534.


A microorganism with close immunohistological and genetic resemblance to Helicobacter pylori was found in the resected gallbladder mucosa of a 41-year-old woman. The woman was admitted to hospital complaining of fever and right hypochondrial pain. Cholecystectomy was carried out under the diagnosis of gallstones and cholecystitis. A microorganism resembling H. pylori (stained with H&E, Giemsa, and Wartin-Starry) was detected incidentally on pathological examination. The microorganism was also positive for immunohistochemical staining. An amplification reaction was seen on genetic examination by the polymerase chain reaction (PCR) method (urease beta-genes). Our findings suggest that H. pylori may be present in tissues other than gastric mucosa.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cholecystitis / microbiology*
  • Cholecystitis / pathology
  • Cholelithiasis / microbiology*
  • Cholelithiasis / pathology
  • DNA, Bacterial / analysis
  • Female
  • Gallbladder / microbiology*
  • Gallbladder / pathology
  • Helicobacter Infections / complications*
  • Helicobacter Infections / diagnosis
  • Helicobacter pylori / isolation & purification*
  • Humans
  • Immunohistochemistry
  • Mucous Membrane / microbiology
  • Mucous Membrane / pathology
  • Polymerase Chain Reaction


  • DNA, Bacterial