Isolation of inhibitors of TPA-induced mouse ear edema from Hoelen, Poria cocos

H Nukaya; H Yamashiro; H Fukazawa; H Ishida; K Tsuji

doi:10.1248/cpb.44.847

Isolation of inhibitors of TPA-induced mouse ear edema from Hoelen, Poria cocos

Chem Pharm Bull (Tokyo). 1996 Apr;44(4):847-9. doi: 10.1248/cpb.44.847.

Authors

H Nukaya¹, H Yamashiro, H Fukazawa, H Ishida, K Tsuji

Affiliation

¹ School of Pharmaceutical Sciences, University of Shizuoka, Japan.

PMID: 8681415
DOI: 10.1248/cpb.44.847

Abstract

Triterpene carboxylic acids were isolated from the methanol extract of Hoelen, Poria cocos, and found to inhibit 12-O-tetradecanoylphorbol 13-acetate (TAP)-induced mouse ear edema. Their chemical structures were identified as 3 beta,-16 alpha-dihydroxylanosta-7,9(11),24-trien-21-oic acid, 16 alpha-hydroxydehydropachymic acid, 16 alpha-hydroxytrametenolic acid and dehydrotumulosic acid.

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
Chromatography, High Pressure Liquid
Ear, External / pathology
Edema / chemically induced
Edema / pathology
Edema / prevention & control*
Magnetic Resonance Spectroscopy
Male
Mice
Plants, Medicinal / chemistry*
Spectrometry, Mass, Fast Atom Bombardment
Tetradecanoylphorbol Acetate*
Triterpenes / isolation & purification*
Triterpenes / pharmacology

Substances

Anti-Inflammatory Agents, Non-Steroidal
Triterpenes
Tetradecanoylphorbol Acetate