Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor

Carcinogenesis. 1996 Jun;17(6):1389-91. doi: 10.1093/carcin/17.6.1389.

Abstract

The physiologically active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D3 (calcitriol), induces gap junctional intercellular communication in human skin fibroblasts 161BR at a concentration of 10(-7) M. In human skin fibroblasts, FIB5, devoid of a functional nuclear vitamin D receptor (VDR), there is no effect on gap junctional intercellular communication. Parallel to the increase in cell-cell communication, we observed a VDR-dependent increase in connexin43 protein and connexin43 mRNA levels. These results suggest that 1alpha,25-dihydroxyvitamin D3 affects gap junctional intercellular communication at the level of transcription or of mRNA stability via the nuclear VDR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcitriol / metabolism
  • Calcitriol / pharmacology
  • Cell Communication / drug effects*
  • Cell Nucleus / metabolism
  • Cell Nucleus / physiology
  • Connexin 43 / metabolism
  • Fibroblasts / cytology*
  • Fibroblasts / drug effects*
  • Fibroblasts / metabolism
  • Gap Junctions / drug effects*
  • Humans
  • RNA, Messenger / metabolism
  • Receptors, Calcitriol / physiology*
  • Skin / cytology*
  • Skin / drug effects*
  • Skin / metabolism
  • Vitamin D / metabolism
  • Vitamin D / pharmacology*

Substances

  • Connexin 43
  • RNA, Messenger
  • Receptors, Calcitriol
  • Vitamin D
  • Calcitriol