Diabetic nephropathy and pregnancy

Obstet Gynecol Clin North Am. 1996 Mar;23(1):173-203. doi: 10.1016/s0889-8545(05)70251-5.

Abstract

Knowledge of the pathogenic mechanisms of diabetic nephropathy (by which hyperglycemia, hyperfiltration, and hypertension cause the gradual development of microproteinuria, mesangial expansion, and eventual glomerular closure) provides the basis for effective treatment. Intensified glycemic control and antihypertensive therapy that is safe for the fetus are crucial for success during pregnancy. Considered outcome measures include perinatal survival, size at birth, child development, and long-term maternal renal function.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Birth Weight
  • Blood Glucose / analysis
  • Child Development
  • Diabetic Nephropathies / etiology
  • Diabetic Nephropathies / physiopathology
  • Diabetic Nephropathies / therapy*
  • Female
  • Fetus
  • Humans
  • Hyperglycemia / complications
  • Hypertension / complications
  • Infant, Newborn
  • Kidney / physiology
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy in Diabetics / physiopathology
  • Pregnancy in Diabetics / therapy*
  • Proteinuria / etiology

Substances

  • Antihypertensive Agents
  • Blood Glucose