Unusual endometrial stromal cell changes mimicking metastatic carcinoma

Pathol Res Pract. 1996 Jan;192(1):33-6. doi: 10.1016/S0344-0338(96)80127-0.


We report an unusual histopathologic finding in the endometrium from six premenopausal or perimenopausal patients who underwent biopsy for abnormal uterine bleeding. In each case the endometrial stromal cells focally exhibited a pronounced epithelioid appearance; some showed a cord-like trabecular pattern and others a signet-ring-like cell change. All raised the possibility of a metastatic malignancy, particularly from the breast. The epithelioid appearance of the stromal cells appears to be an unusual artifact occurring in a background of secretory change and predecidualization with nonmenstrual breakdown.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / pathology*
  • Adenocarcinoma / secondary
  • Adult
  • Biopsy
  • Carcinoma, Lobular / pathology*
  • Carcinoma, Lobular / secondary
  • Diagnosis, Differential
  • Endometrial Neoplasms / pathology*
  • Endometrial Neoplasms / secondary
  • Endometrium / pathology*
  • Female
  • Humans
  • Middle Aged
  • Stromal Cells / pathology
  • Uterine Hemorrhage / pathology