Model-based scatter correction for fully 3D PET

Phys Med Biol. 1996 Jan;41(1):153-76. doi: 10.1088/0031-9155/41/1/012.


A method is presented that directly calculates the mean number of scattered coincidences in data acquired with fully 3D positron emission tomography (PET). This method uses a transmission scan, an emission scan, the physics of Compton scatter, and a mathematical model of the scanner in a forward calculation of the number of events for which one photon has undergone a single Compton interaction. The distribution of events for which multiple Compton interactions have occurred is modelled as a linear transformation of the single-scatter distribution. Computational efficiency is achieved by sampling at rates no higher than those required by the scatter distribution and by implementing the algorithm using look-up tables. Evaluation studies in phantoms with large scatter fractions show that the method yields images with quantitative accuracy equivalent to that of slice-collimated PET in clinically useful times.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms*
  • Humans
  • Models, Theoretical
  • Monte Carlo Method
  • Phantoms, Imaging*
  • Reproducibility of Results
  • Scattering, Radiation
  • Sensitivity and Specificity
  • Tomography, Emission-Computed* / instrumentation
  • Tomography, Emission-Computed* / methods