Soluble E-cadherin concentrations in patients with systemic inflammatory response syndrome and multiorgan dysfunction syndrome

Br J Anaesth. 1996 May;76(5):629-31. doi: 10.1093/bja/76.5.629.


We have assessed the role of the cell-cell adhesion molecule, E-cadherin, in the pathogenesis of multiorgan failure in 24 intensive care patients with sepsis and varying degrees of organ dysfunction, compared with 21 healthy subjects. Plasma soluble E-cadherin (sE-cadherin) was measured by enzyme immunoassay. The median concentration of sE-cadherin in normal subjects was 3.21 micrograms ml-1 compared with 6.00 micrograms ml-1 in patients with sepsis and organ dysfunction (P = 0.0019). There was no statistically significant difference in concentrations of sE-cadherin in survivors compared with non-survivors. Concentrations of sE-cadherin tended to increase with the severity of organ failure. We conclude that sE-cadherin is increased in inflammation and injury, and may be related to the degree of multiorgan failure after sepsis.

MeSH terms

  • Adult
  • Aged
  • Cadherins / blood*
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Middle Aged
  • Multiple Organ Failure / blood*
  • Systemic Inflammatory Response Syndrome / blood*
  • Time Factors


  • Cadherins