Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17

Biochim Biophys Acta. 1996 Jul 17;1307(3):263-6. doi: 10.1016/0167-4781(96)00077-2.


In the present study we have cloned and sequenced two testis-specific cDNAs (1.3 kb and 1.6 kb) encoding a human sperm protein, designated HSp17. Each cDNA gave rise to identical protein sequences and differed only in the 5' untranslated region. The predicted amino-acid sequence revealed a protein of 17.5 kDa which exhibited a high degree of homology with both rabbit and mouse Sp17. Analysis of native and recombinant Sp17 by SDS-PAGE has shown the apparent molecular weight of the protein to be 24.5 kDa.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA, Complementary / chemistry*
  • Humans
  • Male
  • Mice
  • Molecular Sequence Data
  • Proteins / chemistry
  • Proteins / genetics*
  • Rabbits
  • Spermatozoa / chemistry*


  • DNA, Complementary
  • Proteins

Associated data

  • GENBANK/Z48570