Bullous pemphigoid--a report of 86 cases from Taiwan

Clin Exp Dermatol. 1996 Jan;21(1):20-2.


We reviewed 86 cases of bullous pemphigoid and the results were compared with those reported in the literature. Seventy-eight per cent of the patients developed generalized blisters and 22% had localized blisters, including three cases of dyshidrosiform pemphigoid and one case of pretibial pemphigoid. Oral mucosal involvement was noticed in 12.8% of the patients. Fifteen per cent of the patients had internal malignancies but the incidence was not significantly different from the control group. Direct immunofluorescence in our series showed a high positive rate of 98.8%. Indirect immunofluorescence was positive in 48.1% of the 54 patients in whom this was carried out. Peripheral blood eosinophilia was observed in 22.1% of the patients. Prednisolone alone or in combination with immunosuppressive agents was the mainstay of treatment. Treatment side-effects was observed in 33% of the patients. Thirty per cent of the patients had a complete remission after a mean follow-up period of 26.9 months. Bullous pemphigoid (BP) is a chronic debilitating autoimmune blistering disease. It is characterized clinically by generalized tense bullae and histologically by subepidermal blisters. Immunofluorescence is crucial in the diagnosis and shows linear deposits of C3 and/or IgG at the basement membrane zone (BMZ). Information regarding this disease in Chinese patients is quite limited. In this study, 86 patients with BP were reviewed. The clinical and histological features, immunofluorescence, modes of therapy and outcome were studied.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents / therapeutic use
  • Case-Control Studies
  • Child
  • Drug-Related Side Effects and Adverse Reactions
  • Female
  • Fluorescent Antibody Technique, Direct
  • Humans
  • Male
  • Middle Aged
  • Neoplasms / complications
  • Pemphigoid, Bullous / complications
  • Pemphigoid, Bullous / drug therapy
  • Pemphigoid, Bullous / immunology
  • Pemphigoid, Bullous / pathology*
  • Prednisolone / therapeutic use
  • Retrospective Studies
  • Taiwan
  • Treatment Outcome


  • Anti-Inflammatory Agents
  • Prednisolone