The effect of alcohol and smoking on testosterone function and aggression in chronic alcoholics

Am J Psychiatry. 1977 Jun;134(6):621-5. doi: 10.1176/ajp.134.6.621.


Forty alcoholics without other significant medical or psychiatric problems were studied on a research ward for two weeks. All subjects abstained from alcohol and cigarettes during the first week; 30 randomly selected subjects were permitted unlimited alcohol and/or cigarettes during the second week. Plasma testosterone levels were normal during the first week but decreased rapidly and significantly in those subjects allowed alcohol. A variety of measures of affect failed to show a significant correlation between hostility/aggression and plasma testosterone levels or alcohol ingestion.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Affect / drug effects
  • Aggression / drug effects*
  • Alcoholism / complications*
  • Anxiety / etiology
  • Depression / etiology
  • Ethanol / pharmacology*
  • Hostility / drug effects
  • Humans
  • Male
  • Nicotine / pharmacology
  • Smoking / complications*
  • Testosterone / blood*


  • Ethanol
  • Testosterone
  • Nicotine