Despite rapid advances in genetic diagnosis and gene therapy, only a few nurses are addressing the need for widespread dissemination of genetic information. A critical question is: How long will nurses be able to maintain high-quality care and contend with the conundrums of genopathic medicine? The purpose of this state-of-the-science paper is to trace progress in nursing education in genetics and to recommend curriculum change. A recurrent theme-the need for knowledge-is found in nursing studies and national forums in genetics. Genetic knowledge for nurses should be a priority.