Membrane Phospholipid Asymmetry: Host Response to the Externalization of Phosphatidylserine

J Leukoc Biol. 1996 Jun;59(6):784-8. doi: 10.1002/jlb.59.6.784.

Abstract

Membrane phospholipid asymmetry is an important regulator of cellular function and homeostasis. The activities of lipid transporters are contributing factors to the regulation of membrane lipid composition over the lifespan of the cell. Alterations in the activities of these proteins result in the movement of phosphatidylserine to the cell's outer leaflet. This promotes several physiologic responses including initiation of the coagulation cascade and cell recognition by the reticuloendothelial system.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Carrier Proteins / physiology
  • Cell Differentiation
  • Homeostasis
  • Humans
  • Membrane Lipids / analysis*
  • Membrane Lipids / metabolism
  • Membrane Proteins / physiology
  • Phosphatidylserines / analysis*
  • Phosphatidylserines / metabolism
  • Phospholipid Transfer Proteins*

Substances

  • Carrier Proteins
  • Membrane Lipids
  • Membrane Proteins
  • Phosphatidylserines
  • Phospholipid Transfer Proteins