Active site directed inhibition of estrone sulfatase by nonsteroidal coumarin sulfamates

J Med Chem. 1996 Mar 29;39(7):1349-51. doi: 10.1021/jm950931z.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Breast Neoplasms / enzymology
  • Coumarins / chemical synthesis
  • Coumarins / chemistry
  • Coumarins / pharmacology*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Microsomes / enzymology
  • Placenta / enzymology
  • Sulfatases / antagonists & inhibitors*
  • Sulfonamides / chemical synthesis
  • Sulfonamides / chemistry
  • Sulfonamides / pharmacology*
  • Tumor Cells, Cultured

Substances

  • 4-methylcoumarin 7-O-sulfamate
  • Coumarins
  • Enzyme Inhibitors
  • Sulfonamides
  • coumarin 7-O-sulfamate
  • Sulfatases
  • estrone sulfatase