MRI demonstration of a reversible lesion in cerebral deep white matter in thrombotic thrombocytopenic purpura

Neuroradiology. 1996 Feb;38(2):137-8. doi: 10.1007/BF00604799.


We report a 75-year-old woman with thrombotic thrombocytopenic purpura (TTP) whose MRI showed diffuse abnormal signal in the deep white matter. She was successfully treated, and this abnormal signal disappeared. This finding indicates that the deep white matter is involved in TTP; the lesion may reflect reversible microangiopathy and brain oedema.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Atrophy
  • Brain / blood supply*
  • Brain / pathology
  • Brain Edema / diagnosis*
  • Brain Edema / therapy
  • Cerebral Cortex / blood supply
  • Cerebral Cortex / pathology
  • Cerebral Infarction / diagnosis*
  • Cerebral Infarction / therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging*
  • Plasmapheresis
  • Purpura, Thrombotic Thrombocytopenic / diagnosis*
  • Purpura, Thrombotic Thrombocytopenic / therapy