Inhibitory effect of taraxastane-type triterpenes on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin

Oncology. 1996 Jul-Aug;53(4):341-4. doi: 10.1159/000227584.

Abstract

Two taraxastane-type hydroxy triterpenes, taraxasterol and faradiol, isolated from the flowers of Compositae plants Cynara scolymus (artichoke) and Chrysanthemum morifilolium (chrysanthemum), respectively, showed strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. At 2.0 mumol/mouse, these compounds inhibited markedly the tumor-promoting effect of TPA (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[alpha]anthracene (50 micrograms/mouse).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene / toxicity
  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Carcinogens / toxicity*
  • Drugs, Chinese Herbal
  • Edema / chemically induced
  • Edema / prevention & control
  • Female
  • Inflammation
  • Mice
  • Mice, Inbred ICR
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / prevention & control*
  • Sterols / pharmacology*
  • Tetradecanoylphorbol Acetate / toxicity*
  • Triterpenes / pharmacology*
  • Vegetables

Substances

  • Anticarcinogenic Agents
  • Carcinogens
  • Drugs, Chinese Herbal
  • Sterols
  • Triterpenes
  • 9,10-Dimethyl-1,2-benzanthracene
  • taraxasterol
  • Tetradecanoylphorbol Acetate
  • faradiol