Treatment of persistent glaucoma secondary to periocular corticosteroids

Am J Ophthalmol. 1996 Aug;122(2):275-7. doi: 10.1016/s0002-9394(14)72027-6.


Purpose: To describe two patients with uveitis who developed increased intraocular pressure that was unresponsive to maximum medical therapy eight and 13 months after periocular injection of triamcinolone acetonide.

Methods: Excised periocular tissue was analyzed for corticosteroid activity by gas chromatography and mass spectrometry.

Results: Excision of the periocular tissue, which contained visible triamcinolone acetonide, resulted in a normal intraocular pressure within 14 days in both patients. Analysis of the excised tissue disclosed residual corticosteroid in one of the two patients.

Conclusion: Removal of periocular tissue containing injected corticosteroids may facilitate the management of patients developing increased intraocular pressure unresponsive to maximum medical therapy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Inflammatory Agents / adverse effects*
  • Anti-Inflammatory Agents / therapeutic use
  • Antihypertensive Agents / therapeutic use
  • Child
  • Fasciotomy
  • Glaucoma / chemically induced
  • Glaucoma / therapy*
  • Humans
  • Injections
  • Intraocular Pressure
  • Male
  • Middle Aged
  • Ocular Hypertension / chemically induced
  • Ocular Hypertension / therapy
  • Orbit / drug effects
  • Orbit / surgery
  • Triamcinolone Acetonide / adverse effects*
  • Triamcinolone Acetonide / therapeutic use
  • Uveitis / complications
  • Uveitis / drug therapy


  • Anti-Inflammatory Agents
  • Antihypertensive Agents
  • Triamcinolone Acetonide