A comparison of the induction characteristics of sevoflurane and halothane in children

Anaesthesia. 1996 Jun;51(6):539-42. doi: 10.1111/j.1365-2044.1996.tb12559.x.

Abstract

The induction characteristics of sevoflurane and halothane were compared in 81 children aged 6 months to 6 years. The mean time taken to achieve loss of eyelash reflex was significantly shorter with sevoflurane than with halothane (sevoflurane, mean time (SD) 1 min 41 s (35 s), halothane, mean time (SD) 2 min 17 s (43 s), t = 4.11, p = < 0.01). The mean time taken to complete induction (to achieve steady spontaneous ventilation and small pupils with central gaze) was also shorter in children induced with sevoflurane (sevoflurane, mean time (SD) 3 min 58 s (1 min 8 s), halothane, mean time (SD) 4 min 50 s, (1 min 27 s), t = 2.29, p = 0.027). Effects on heart rate, blood pressure and oxygen saturation during induction were similar for both agents. There were no major complications during induction with either halothane or sevoflurane.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase III
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Anesthesia, Inhalation / methods
  • Anesthetics, Inhalation*
  • Blood Pressure / drug effects
  • Child
  • Child, Preschool
  • Consciousness / drug effects
  • Ethers*
  • Female
  • Halothane*
  • Heart Rate / drug effects
  • Humans
  • Infant
  • Male
  • Methyl Ethers*
  • Oxygen / blood
  • Sevoflurane
  • Time Factors

Substances

  • Anesthetics, Inhalation
  • Ethers
  • Methyl Ethers
  • Sevoflurane
  • Oxygen
  • Halothane