Phosphatidylethanolamine methylation and hepatoma cell growth

Anticancer Res. 1996 May-Jun;16(3B):1413-6.


Phosphatidylethanolamine is converted to phosphatidylcholine in hepatocytes via the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). An isoform, PEMT2 has been cloned, expressed and localized to a mitochondria-associated membrane in rat liver. Expression of PEMT2 caused a decreased rate of cell division of cultured rat hepatoma cells. Mechanistic studies suggest that the slower growth of transfected hepatoma cells may be due to down regulation of CTP: phosphocholine cytidylyltransferase and the CDP-choline pathway for phosphatidylcholine biosynthesis. A role for PEMT2 in the regulation of hepatocyte cell division is also indicated by PEMT2 down-regulation in regenerating rat liver.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Choline-Phosphate Cytidylyltransferase
  • Liver Neoplasms, Experimental / metabolism*
  • Liver Neoplasms, Experimental / pathology
  • Methylation
  • Methyltransferases / physiology*
  • Nucleotidyltransferases / metabolism
  • Phosphatidylethanolamine N-Methyltransferase
  • Phosphatidylethanolamines / metabolism*
  • Rats


  • Phosphatidylethanolamines
  • Methyltransferases
  • Phosphatidylethanolamine N-Methyltransferase
  • Nucleotidyltransferases
  • Choline-Phosphate Cytidylyltransferase