Mobile lipid accumulation in necrotic tissue of high grade astrocytomas

Anticancer Res. May-Jun 1996;16(3B):1485-9.


Multiple samples from 42 astrocytomas were investigated ex vivo by 1H MR spectroscopy followed by histological assessment. MR visible lipids were detected in 27 of 32 grade 4 astrocytomas. These lipids were heterogeneously distributed within the tumours. Their amount correlated positively with the amount of histologically detected necrosis. Mobile lipids were also observed in grade 4 astrocytoma samples without necrosis, as well as in one of three grade 3, two of three grade 2 and two of four grade 1 astrocytomas. The clinical significance of MR visible lipids, their cellular location, and their possible biological bases are discussed.

MeSH terms

  • Astrocytoma / metabolism*
  • Astrocytoma / pathology
  • Humans
  • Lipid Metabolism*
  • Magnetic Resonance Spectroscopy
  • Necrosis