Strong cytolytic activity of natural killer cells is neither necessary nor sufficient for preimmune resistance to Toxoplasma gondii infection

Nat Immun. 1995 Apr;14(4):209-15.

Abstract

That strong cytolytic activity of natural killer (NK) cells is neither necessary nor sufficient for defense against acute Toxoplasma gondii infection is demonstrated. T. gondii-infected anti-interferon (IFN)-gamma-treated mice and IFN-gamma gene knockout mice died despite good induction of NK activity, while infected beige mice, deficient in NK cytolytic activity, survived.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cytotoxicity, Immunologic / immunology
  • Immunity, Innate
  • Interferon-gamma / immunology
  • Killer Cells, Natural / immunology*
  • Mice
  • Mice, Inbred C57BL
  • Toxoplasmosis, Animal / immunology*

Substances

  • Interferon-gamma