Recent developments in DNA topoisomerase II structure and mechanism

Curr Opin Struct Biol. 1996 Feb;6(1):84-90. doi: 10.1016/s0959-440x(96)80099-6.

Abstract

Type II DNA topoisomerases are enzymes that are capable of transporting one duplex DNA through another. Recent experimental results, including the structure of a fragment of yeast topoisomerase II, have provided new insights into the mechanism of the strand passage reaction. Other results have begun to define the role of ATP in the catalytic cycle and illuminate how DNA breaks mediated by topoisomerase II can occur.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism
  • Binding Sites
  • Catalysis
  • Crystallography, X-Ray
  • DNA / metabolism
  • DNA Gyrase
  • DNA Topoisomerases, Type II / chemistry*
  • DNA Topoisomerases, Type II / metabolism
  • DNA, Bacterial / metabolism
  • DNA, Fungal / metabolism
  • Fungal Proteins / chemistry
  • Fungal Proteins / metabolism
  • Models, Molecular
  • Protein Binding
  • Saccharomyces cerevisiae / enzymology
  • Structure-Activity Relationship

Substances

  • Bacterial Proteins
  • DNA, Bacterial
  • DNA, Fungal
  • Fungal Proteins
  • Adenosine Triphosphate
  • DNA
  • DNA Gyrase
  • DNA Topoisomerases, Type II