Bone mineral density of the spine using dual energy X-ray absorptiometry in patients with non-insulin-dependent diabetes mellitus

J Obstet Gynaecol Res. 1996 Apr;22(2):157-62. doi: 10.1111/j.1447-0756.1996.tb00959.x.


To evaluate the influence of non-insulin-dependent diabetes mellitus (NIDDM) on bone mineral density (BMD), we measured BMD in 185 female patients with NIDDM using dual energy X-ray absorptiometry (DEXA). BMD was measured in lumbar vertebrae (L2-4). BMD is slightly higher in the diabetic patients compared with control subjects and bone loss related to menopause starts before the onset of menopause. The BMD of postmenopausal women showed a definite decrease with aging and there was abrupt bone loss after 55 years of age (p < 0.05). In relation to the duration of diabetes, the decrease of BMD for 15 years was 10.0%. BMD was negatively correlated with age, years since menopause (YSM), and disease duration (r = -0.584, r = -0.470, r = -0.186). These results suggest that age, YSM, and the duration of disease appear to be the risk factors for decreased BMD in the diabetic patients.

MeSH terms

  • Absorptiometry, Photon*
  • Adult
  • Aged
  • Aging
  • Bone Density* / physiology
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / diagnostic imaging
  • Diabetes Mellitus, Type 2 / metabolism*
  • Female
  • Humans
  • Korea
  • Lumbar Vertebrae / diagnostic imaging
  • Lumbar Vertebrae / metabolism*
  • Middle Aged
  • Osteoporosis / diagnostic imaging
  • Osteoporosis / metabolism
  • Postmenopause
  • Risk Factors