Chlamydial cervicitis and urethritis: single dose treatment compared with doxycycline for seven days in community based practises

Genitourin Med. 1996 Apr;72(2):93-7. doi: 10.1136/sti.72.2.93.


Study goal: To compare the efficacy and safety of single 1 g oral azithromycin with doxycycline, 100 mg twice daily for seven days for treatment of uncomplicated urogenital chlamydial infection.

Study design: Randomised, unblinded, comparative trial, involving 597 patients demonstrating clinical evidence of genital chlamydia and a positive non-culture assay for Chlamydia trachomatis.

Results: Among the azithromycin- and doxycycline-treated patients 61% and 60%, respectively, were asymptomatic within one week after the first dose. At two weeks, these figures increased to 86% and 83%, respectively. Bacteriological eradication, based on a negative assay, occurred in 338 (97%) of 347 azithromycin-treated patients and 161 (99%) of 163 doxycycline-treated patients.

Conclusion: Treatment of uncomplicated chlamydial cervicitis and urethritis with single 1 g oral azithromycin is equivalent to standard therapy with doxycycline. Drug-related adverse events were approximately twice as common as previously reported for both drugs.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Azithromycin / administration & dosage*
  • Azithromycin / adverse effects
  • Chlamydia Infections / drug therapy*
  • Chlamydia trachomatis*
  • Doxycycline / administration & dosage
  • Doxycycline / adverse effects
  • Female
  • Humans
  • Male
  • Middle Aged
  • Treatment Outcome
  • Urethritis / drug therapy*
  • Urethritis / microbiology
  • Uterine Cervicitis / drug therapy*
  • Uterine Cervicitis / microbiology


  • Anti-Bacterial Agents
  • Azithromycin
  • Doxycycline