Abstract
Synthetic peptides and murine monoclonal antibodies were used to map cross-reactive chlamydial epitopes. A species-specific epitope in the central region of variable sequence region 4 abuts the amino-terminal end of a B-serogroup-specific or F/G-serogroup-specific epitope, which in turn abuts known serovar-specific epitopes. The carboxyl-terminal portion of variable sequence region 4 (residues 297 to 314) comprises a region of end-to-end B-cell epitopes in some serovars of the B and F/G serogroups.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Antibodies, Bacterial
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Antibodies, Monoclonal
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Antigens, Bacterial / genetics
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / immunology*
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Chlamydia Infections / immunology
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Chlamydia Infections / prevention & control
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Chlamydia trachomatis / classification
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Chlamydia trachomatis / genetics
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Chlamydia trachomatis / immunology*
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Cross Reactions
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Epitope Mapping
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Epitopes / genetics
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Mice
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Molecular Sequence Data
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Serotyping
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Species Specificity
Substances
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Antibodies, Bacterial
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Antibodies, Monoclonal
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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Epitopes