Treatment of scleromyxedema with 2-chlorodeoxyadenosine

J Am Acad Dermatol. 1996 Aug;35(2 Pt 2):288-90. doi: 10.1016/s0190-9622(96)90650-7.

Abstract

Scleromyxedema is an unusual skin disease that is characterized by a proliferation of fibroblasts and an accumulation of mucin. Despite experience with multiple forms of therapy, no single agent has proved uniformly beneficial in this condition. We describe a patient with scleromyxedema who was treated successfully with 2-chlorodeoxyadenosine (2-CdA), a purine analog used mainly in the treatment of lymphoproliferative disorders.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cladribine / therapeutic use*
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use*
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Myxedema / pathology*
  • Scleroderma, Systemic / pathology*

Substances

  • Immunosuppressive Agents
  • Cladribine