Interleukin-6 production by human neonatal monocytes stimulated by type III group B streptococci

J Infect Dis. 1996 Aug;174(2):332-7. doi: 10.1093/infdis/174.2.332.


The subcellular components of type III group B streptococci (GBS) that contribute to the host inflammatory response were determined by measuring production of the proinflammatory cytokine interleukin (IL)-6 by cord blood monocytes. Monocytes were stimulated with encapsulated (COH1) or unencapsulated (COH1-13) whole type III GBS or with purified GBS components, including type III capsular polysaccharide (III-PS), group B antigen (GB-Ag), lipoteichoic acid (LTA), or Escherichia coli lipopolysaccharide. Monocytes exposed to COH1 and COH1-13 released similar amounts of IL-6. GBS III-PS, GB-Ag, and LTA each induced IL-6. However, IL-6 release by monocytes was significantly greater after stimulation by GB-Ag than by III-PS or LTA (P < .05). Sera from 16 neonates with systemic GBS disease had IL-6 levels of 8 pg/mL to 4.28 ng/mL. GB-Ag is a potent inducer of IL-6 and may play an important role in tissue inflammation during GBS infection.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antigens, Bacterial / pharmacology
  • Bacterial Capsules / pharmacology
  • Cells, Cultured
  • Fetal Blood / cytology
  • Humans
  • Infant, Newborn
  • Interleukin-6 / biosynthesis*
  • Lipopolysaccharides / pharmacology
  • Monocytes / drug effects
  • Monocytes / metabolism*
  • Monocytes / microbiology
  • Streptococcal Infections / immunology
  • Streptococcus agalactiae / immunology*
  • Teichoic Acids / pharmacology


  • Antigens, Bacterial
  • Interleukin-6
  • Lipopolysaccharides
  • Teichoic Acids
  • lipoteichoic acid