Etiology of the acrodermatitis chronica atrophicans lesion in Lyme disease

J Infect Dis. 1996 Aug;174(2):421-3. doi: 10.1093/infdis/174.2.421.

Abstract

Spirochete diversity in acrodermatitis chronica atrophicans lesions in a closely defined central European site was compared to that in the local vector population, in human erythema migrans lesions, and in cerebrospinal fluid by amplifying and sequencing a segment of the gene of outer surface protein A directly from sampled tissues. Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi acutely infect human skin and invade internal tissues. Only B. afzelii, however, is associated with acrodermatitis chronica atrophicans lesions, persisting chronically where the skin has atrophied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrodermatitis / epidemiology
  • Acrodermatitis / etiology*
  • Acrodermatitis / microbiology*
  • Animals
  • Antigens, Surface / genetics
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Vaccines
  • Borrelia / classification*
  • Borrelia / genetics
  • Borrelia / isolation & purification
  • Borrelia Infections / complications
  • Borrelia Infections / epidemiology
  • Borrelia Infections / microbiology*
  • Germany / epidemiology
  • Humans
  • Lipoproteins*
  • Lyme Disease / complications
  • Lyme Disease / epidemiology
  • Lyme Disease / microbiology*
  • Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Ticks / microbiology

Substances

  • Antigens, Surface
  • Bacterial Outer Membrane Proteins
  • Bacterial Vaccines
  • Lipoproteins
  • OspA protein