Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis

Arthritis Rheum. 1977 Jun;20(5):1037-42. doi: 10.1002/art.1780200501.


Thirty-nine patients with rheumatoid arthritis were HLA typed for the full range of A and B locus specificities and for Cw3 and Dw4. HLA-Dw4 was significantly more frequent in patients (36%) than in controls (13%). The frequency of Cw3 was also increased, probably because this allele is in linkage disequilibrium with Dw4.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Arthritis, Rheumatoid / genetics
  • Arthritis, Rheumatoid / immunology*
  • Female
  • Gene Frequency
  • Genetic Linkage
  • HLA Antigens / analysis*
  • Histocompatibility Antigens / analysis*
  • Homozygote
  • Humans
  • Male


  • HLA Antigens
  • Histocompatibility Antigens