Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene

Nature. 1996 Jul 11;382(6587):133-8. doi: 10.1038/382133a0.

Abstract

Appendage formation is organized by signals from discrete sources that presumably act upon downstream genes to control growth and patterning. The Drosophila vestigial gene is selectively required for wing-cell proliferation, and is sufficient to induce outgrowths of wing tissue from eyes, legs and antennae. Different signals activate separate enhancers to control vestigial expression: first, in the dorsal/ventral organizer through the Notch pathway, and subsequently, in the developing wing blade by decapentaplegic and a signal from the dorsal/ventral organizer. Signal integration must be a general feature of genes like vestigial, that regulate growth or patterning along more than one axis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • DNA
  • DNA Footprinting
  • Drosophila / embryology
  • Drosophila / genetics*
  • Drosophila Proteins*
  • Enhancer Elements, Genetic
  • Gene Expression Regulation, Developmental*
  • Insect Hormones / physiology
  • Molecular Sequence Data
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / physiology
  • Repressor Proteins / physiology
  • Signal Transduction*
  • Wings, Animal / embryology*

Substances

  • Drosophila Proteins
  • Insect Hormones
  • Nuclear Proteins
  • Repressor Proteins
  • Su(H) protein, Drosophila
  • dpp protein, Drosophila
  • vg protein, Drosophila
  • DNA