A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

Nature. 1996 Aug 8;382(6591):536-9. doi: 10.1038/382536a0.


A pheromone-induced neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity at the dauer diapause stage. The gene age-1 is required for non-dauer development and normal senescence. age-1 encodes a homologue of mammalian phosphatidylinositol-3-OH kinase (PI(3)K) catalytic subunits. Lack of both maternal and zygotic age-1 activity causes dauer formation, whereas animals with maternal but not zygotic age-1 activity develop as non-dauers that live more than twice as long as normal. These data suggest that phosphatidylinositol signalling mediated by AGE-1 protein controls lifespan and the dauer diapause decision.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Caenorhabditis elegans / enzymology*
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / physiology
  • Caenorhabditis elegans Proteins*
  • Chromosome Mapping
  • Helminth Proteins / genetics
  • Helminth Proteins / physiology*
  • Longevity / physiology*
  • Molecular Sequence Data
  • Mutation
  • Phosphatidylinositol 3-Kinases
  • Phosphatidylinositols / metabolism
  • Phosphotransferases (Alcohol Group Acceptor) / genetics
  • Phosphotransferases (Alcohol Group Acceptor) / physiology*
  • Signal Transduction


  • Caenorhabditis elegans Proteins
  • Helminth Proteins
  • Phosphatidylinositols
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • AGE-1 protein, C elegans

Associated data

  • GENBANK/U56101
  • SWISSPROT/P42337