[Systemic mastocytosis as a cause of osteoporosis]

Ned Tijdschr Geneeskd. 1996 Jun 15;140(24):1277-9.
[Article in Dutch]


Out of 21 male patients with osteoporosis who visited an outpatient clinic for endocrine diseases in two years (1994-1995), three had systemic mastocytosis as diagnosed histopathologically. Two of these had characteristic features of urticaria pigmentosa, consisting of multiple brown nodules on the skin of trunk and extremities, and a positive Darier sign. In all of them the excretion of the histamine metabolites methylhistamine and methylimidazoleacetic acid in a 24-hour urine specimen was increased. When osteoporosis is diagnosed in men or premenopausal women, underlying pathology could be considered. Cautious investigation of signs and symptoms of systemic mastocytosis in such patients might prove this disease be less rare than is often assumed.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Absorptiometry, Photon
  • Adult
  • Calcium Carbonate / therapeutic use
  • Etidronic Acid / therapeutic use
  • Humans
  • Imidazoles / urine
  • Male
  • Mastocytosis / complications*
  • Methylhistamines / urine
  • Middle Aged
  • Osteoporosis / diagnosis
  • Osteoporosis / drug therapy
  • Osteoporosis / etiology*
  • Urticaria Pigmentosa / complications


  • Imidazoles
  • Methylhistamines
  • methylimidazoleacetic acid
  • Calcium Carbonate
  • Etidronic Acid