Five common conditions and several less common ones cause eyelid dermatitis. Diagnosis and treatment depend on recognizing their characteristics, obtaining a good history, performing a careful skin examination, administering and interpreting patch tests, prescribing the proper medications at the right time, and teaching the patient how to avoid trouble in the future. A case report illustrates the importance of integration and progression of diagnostic and therapeutic steps in resolving the management challenges of eyelid dermatitis.