Efficacy of ciprofloxacin in the eradication of Helicobacter pylori

South Med J. 1996 Aug;89(8):775-8. doi: 10.1097/00007611-199608000-00004.


In small preliminary trials, ciprofloxacin has failed to eradicate Helicobacter pylori. Since fluoroquinolones have a marked reduction in bactericidal activity at acidic pH, we altered the gastric pH using omeprazole and investigated the efficacy of ciprofloxacin in eradicating H pylori. Forty-four consecutive patients infected with H pylori were prospectively studied in a randomized, double-blind, controlled trial comparing ciprofloxacin with a placebo for 2 weeks. Both treatment groups received bismuth and omeprazole. In 36 patients, follow-up endoscopy was done 4 weeks after the cessation of all study drugs. The H pylori infection cleared in 13 of 17 patients (76%) in the ciprofloxacin group versus 5 of 19 (26%) in the placebo group. Concurrent administration of omeprazole with ciprofloxacin resulted in increased bactericidal activity against H pylori. Ciprofloxacin when combined with omeprazole and bismuth is efficacious for eradication of H pylori.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Antacids / therapeutic use
  • Anti-Infective Agents / therapeutic use*
  • Anti-Ulcer Agents / therapeutic use*
  • Bismuth / therapeutic use
  • Ciprofloxacin / therapeutic use*
  • Double-Blind Method
  • Drug Therapy, Combination
  • Duodenal Ulcer / drug therapy*
  • Female
  • Gastroscopy
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori*
  • Humans
  • Male
  • Middle Aged
  • Omeprazole / therapeutic use*
  • Prospective Studies


  • Antacids
  • Anti-Infective Agents
  • Anti-Ulcer Agents
  • Ciprofloxacin
  • Omeprazole
  • Bismuth