Post-translational protein translocation: not all hsc70s are created equal

Trends Biochem Sci. 1996 Apr;21(4):122-6.

Abstract

Hsc70s in the yeast endoplasmic reticulum (ER) and mitochondria interact with membrane-associated components of the translocation machinery and are required for post-translational protein import. Although it has been proposed that the mitochondrial and ER machines function similarly, a variety of experiments suggest that BiP, the ER hsc70, might play a more elaborate role.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Carrier Proteins / metabolism*
  • Fungal Proteins / metabolism*
  • HSC70 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins / metabolism*
  • Protein Processing, Post-Translational*
  • Saccharomyces cerevisiae / metabolism*

Substances

  • Carrier Proteins
  • Fungal Proteins
  • HSC70 Heat-Shock Proteins
  • HSP70 Heat-Shock Proteins