The S100 family of EF-hand calcium-binding proteins: functions and pathology

Trends Biochem Sci. 1996 Apr;21(4):134-40. doi: 10.1016/s0968-0004(96)80167-8.


Calcium lons as second messengers control many biological processes, at least in part, via interaction with a large number of Ca(2+)-binding proteins. One class of these proteins shares a common Ca(2+)-binding motif, the EF-hand, Here, we describe some functional aspects of EF-hand proteins, which have been found recently in different cellular compartments. Novel links between EF-hand proteins, particularly S100 proteins, and specific diseases are now emerging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Calcium-Binding Proteins / physiology*
  • Protein Structure, Secondary*
  • S100 Proteins / physiology*


  • Calcium-Binding Proteins
  • S100 Proteins