Angiocentric immunoproliferative lesions of the lymph node

Am J Clin Pathol. 1996 Jul;106(1):69-77. doi: 10.1093/ajcp/106.1.69.


Clinicopathologic features in 14 cases of lymph node-involved angiocentric immunoproliferative lesions (AILs) are reported. They were selected from 900 cases of lymphoproliferative disorders registered at the Department of Pathology, Fukuoka University. Four cases showed a histologic feature of AIL grade II (AIL-II) and 10 had angiocentric lymphoma (AIL-III). Immunohistologically, transformed B cells were mixed with a large number of small T cells in AIL-II. In AIL-III, there were five cases with B-cell lymphoma, and three had peripheral T-cell lymphoma with no expression of natural-killer (NK)-associated antigens. In the remaining two cases, lymphoma cells expressed both T-cell- and NK-associated antigens. These findings indicate that lymph node-involved AILs are rarely occurring (1.6%) and phenotypically different from sinonasal and cutaneous AILs. Furthermore, NK-associated antigen-positive AILs were found to rarely involve the lymph node. For Epstein-Barr virus (EBV) infection, seven cases of AILs showed many atypical lymphocytes that were positive for EBV-encoded RNA (EBER-1) by using the in situ hybridization analysis. Among them, six cases had latent membrane protein (LMP) positive and EBV nuclear antigen 2 (EBNA-2) negative atypical lymphocytes. The pattern of latent EBV infection was similar to that of Hodgkin's disease, but differed from those of sinonasal T-cell lymphoma and other subtypes of non-Hodgkin's lymphoma. Clinically, 12 patients, including all 4 AIL-II, died within 22 months of the onset of the disease, despite intensive therapy, suggesting that lymph node-involved AILs have a poor prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antigens, Viral / analysis
  • Base Sequence
  • DNA-Binding Proteins / analysis
  • Diagnosis, Differential
  • Epstein-Barr Virus Nuclear Antigens
  • Female
  • Herpesvirus 4, Human / chemistry
  • Humans
  • Immunophenotyping
  • In Situ Hybridization
  • Lymph Nodes / chemistry
  • Lymph Nodes / pathology*
  • Lymphomatoid Granulomatosis / diagnosis*
  • Lymphomatoid Granulomatosis / drug therapy
  • Lymphomatoid Granulomatosis / pathology*
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • RNA-Binding Proteins / analysis
  • Ribosomal Proteins*
  • Viral Matrix Proteins / analysis


  • Antigens, Viral
  • DNA-Binding Proteins
  • EBV-associated membrane antigen, Epstein-Barr virus
  • Epstein-Barr Virus Nuclear Antigens
  • RNA-Binding Proteins
  • Ribosomal Proteins
  • Viral Matrix Proteins
  • RPL22 protein, human