Vincristine-induced alterations in Schwann cells of mouse peripheral nerve

Am J Hematol. 1996 Aug;52(4):254-7. doi: 10.1002/(SICI)1096-8652(199608)52:4<254::AID-AJH3>3.0.CO;2-R.

Abstract

The sciatic nerve of C57Bl mice was examined with a transmission electron microscope to study the ultrastructural alterations in Schwann cells following treatment with escalating doses of vincristine. Results indicated that the drug exerts a dose-related effect. Total doses up to 8 micrograms/mouse did not cause any visible damage to Schwann cells. Higher doses induced not only damage to individual cells, but also affected a greater percentage of them. The myelin sheath was the most affected organelle. Schwann cells of myelinated fibers showed greater damage than those of unmyelinated fibers.

MeSH terms

  • Animals
  • Axons / drug effects
  • Axons / ultrastructure
  • Cell Nucleus / drug effects
  • Cell Nucleus / ultrastructure
  • Mice
  • Mice, Inbred C57BL
  • Microscopy, Electron
  • Myelin Sheath / drug effects
  • Myelin Sheath / ultrastructure
  • Nerve Fibers / drug effects
  • Nerve Fibers / ultrastructure
  • Schwann Cells / drug effects*
  • Schwann Cells / ultrastructure*
  • Sciatic Nerve / drug effects*
  • Sciatic Nerve / ultrastructure*
  • Vincristine / pharmacology*

Substances

  • Vincristine