In vitro selective modulation of cellular glutathione by a humanized native milk protein isolate in normal cells and rat mammary carcinoma model

Anticancer Res. May-Jun 1996;16(3A):1095-9.

Abstract

We report the in vitro selective inhibitory activity of a humanized whey protein concentrate IMMUNOCAL on growth of mammary carcinoma cells and Jurkat T cells in comparison to normal peripheral blood mononuclear cells. We relate this inhibitory activity to a selective depletion of intracellular glutathione synthesis. The use of humanized whey protein concentrate as a food supplementation may have direct implication in clinical trial with adjuvant chemotherapy.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cell Division / drug effects
  • Cell Division / physiology
  • Female
  • Glutathione / biosynthesis*
  • Glutathione / blood
  • Humans
  • Leukocytes, Mononuclear / drug effects*
  • Leukocytes, Mononuclear / metabolism*
  • Mammary Neoplasms, Experimental / metabolism*
  • Milk Proteins / pharmacology*
  • Rats
  • Rats, Inbred F344
  • Reference Values
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / metabolism
  • Tumor Cells, Cultured / drug effects
  • Whey Proteins

Substances

  • Milk Proteins
  • Whey Proteins
  • Glutathione